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[] The common factor in all COVID-19-associated disorders appears to be disrupted redox (reductionoxidation system) homeostasis, which is associated with reactive oxygen species (ROS) deposition and is usually neutralized by antioxidants, the most common of which is glutathione (GSH) where it is produced in the liver from three amino acids (glycine, cysteine, and glutamate) and is vital for the immune system

This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase

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